2024 ICD-10-CM Diagnosis Code C22.1

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Intrahepatic bile duct carcinoma

  • C22.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2024 edition of ICD-10-CM C22.1 became effective on October 1, 2023.
  • This is the American ICD-10-CM version of C22.1 – other international versions of ICD-10 C22.1 may differ.

Applicable To

  • Cholangiocarcinoma

Type 1 Excludes

  • malignant neoplasm of hepatic duct (C24.0)

The following code(s) above C22.1 contain annotation back-references

 that may be applicable to C22.1:

  • C00-D49  Neoplasms
  • C15-C26  Malignant neoplasms of digestive organs
  • C22  Malignant neoplasm of liver and intrahepatic bile ducts

Approximate Synonyms

  • Adenocarcinoma, intrahepatic bile duct
  • Cancer of the bile ducts, intrahepatic
  • Cancer of the liver, cholangiocarcinoma
  • Cholangiocarcinoma of biliary tract
  • Malignant neoplasm of intrahepatic gall duct
  • Primary adenocarcinoma of intrahepatic bile duct

Clinical Information

  • (ko-lan-jee-o-sar-ko-ma) a tumor of the connective tissues of the bile ducts.
  • A carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.
  • A carcinoma that arises from the intrahepatic biliary tree (intrahepatic cholangiocarcinoma) or from the junction, or adjacent to the junction, of the right and left hepatic ducts (hilar cholangiocarcinoma). Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.
  • A malignant neoplasm arising from/comprising cells resembling those of bile ducts.
  • A malignant neoplasm of the liver arising from/comprising cells resembling those of bile ducts.
  • A malignant tumor arising from the intrahepatic bile duct epithelium. It is composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant stroma. (from holland et al., cancer medicine, 3d ed, p1455; stedman, 25th ed)
  • A rare type of cancer that develops in cells that line the bile ducts in the liver. Cancer that forms where the right and left ducts meet is called klatskin tumor.
  • An malignant tumor composed of cells resembling those of bile ducts. Cholangiocarcinoma is a relatively rare tumor in most populations. It can arise from any portion of the intrahepatic bile duct epithelium or the hepatic ducts. Grossly, the lesions are nodular, grayish-white firm and solid. Microscopically, the vast majority of cholangiocarcinomas are adenocarcinomas showing tubular and/or papillary structures. Early detection of cholangiocarcinomas is difficult, and the overall prognosis after resection is poor (adapted from who, 2000).

ICD-10-CM C22.1 is grouped within Diagnostic Related Group(s) (MS-DRG v41.0):

  • 435 Malignancy of hepatobiliary system or pancreas with mcc
  • 436 Malignancy of hepatobiliary system or pancreas with cc
  • 437 Malignancy of hepatobiliary system or pancreas without cc/mcc

Convert C22.1 to ICD-9-CMCode History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change

Code annotations containing back-references to C22.1:

  • Type 1 Excludes: C24

Diagnosis Index entries containing back-references to C22.1: