Liver cell carcinoma
- C22.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
- The 2024 edition of ICD-10-CM C22.0 became effective on October 1, 2023.
- This is the American ICD-10-CM version of C22.0 – other international versions of ICD-10 C22.0 may differ.
Applicable To
- Hepatocellular carcinoma
- Hepatoma
The following code(s) above C22.0 contain annotation back-references
that may be applicable to C22.0:
- C00-D49 Neoplasms
- C15-C26 Malignant neoplasms of digestive organs
- C22 Malignant neoplasm of liver and intrahepatic bile ducts
Approximate Synonyms
- Cancer of the liver, hepatocellular
- Liver cell carcinoma (clinical)
Clinical Information
- (hep-a-toe-ma) a liver tumor.
- (hep-a-toe-sel-yoo-ler kar-sin-o-ma) a type of adenocarcinoma, the most common type of liver tumor.
- A malignant neoplasm arising from hepatocytes.
- A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all african countries south of the sahara and in southeast asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis b, hepatitis c, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.
- A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with epithelial cells indistinguishable from normal hepatocytes to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form giant cells. Several classification schemes have been suggested.
- A type of adenocarcinoma and the most common type of liver tumor.
- New abnormal liver tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease; do not confuse with intrahepatic neoplasm as that may refer to bile duct neoplasm (biliary tract neoplasm).
- Primary malignant neoplasm of epithelial liver cells; it ranges from a well-differentiated tumor with epithelial cells indistinguishable from normal hepatocytes to a poorly differentiated neoplasm; the cells may be uniform or markedly pleomorphic, or form giant cells; associations exist with chronic hepatitis b virus infection, some types of cirrhosis, and hepatitis c virus infection.
- Tumors or cancer of the liver.
ICD-10-CM C22.0 is grouped within Diagnostic Related Group(s) (MS-DRG v41.0):
- 435 Malignancy of hepatobiliary system or pancreas with mcc
- 436 Malignancy of hepatobiliary system or pancreas with cc
- 437 Malignancy of hepatobiliary system or pancreas without cc/mcc
Convert C22.0 to ICD-9-CMCode History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- 2023 (effective 10/1/2022): No change
- 2024 (effective 10/1/2023): No change
Diagnosis Index entries containing back-references to C22.0:
- Cancer – see also Neoplasm, by site, malignant
- hepatocellular C22.0
- Carcinoma (malignant) – see also Neoplasm, by site, malignant
- bile duct
- with hepatocellular, mixed C22.0
- hepatocellular C22.0
- with bile duct, mixed C22.0
- fibrolamellar C22.0
- hepatic cell C22.0
- hepatocholangiolitic C22.0
- liver cell C22.0
- bile duct
- Cholangiocarcinoma
- with hepatocellular carcinoma, combined C22.0
- Cholangiohepatoma C22.0
- Embryoma – see also Neoplasm, uncertain behavior, by site
- malignant – see also Neoplasm, malignant, by site
- liver C22.0
- liver C22.0
- malignant – see also Neoplasm, malignant, by site
- Hepatocarcinoma C22.0
- Hepatocholangiocarcinoma C22.0
- Hepatoma (malignant) C22.0
- embryonal C22.0