Malignant neoplasm of placenta C58-

by

Malignant neoplasm of placenta C58-

Type 1 Excludes

  • chorioadenoma (destruens) (D39.2)
  • hydatidiform mole NOS (O01.9)
  • invasive hydatidiform mole (D39.2)
  • male choriocarcinoma NOS (C62.9-)
  • malignant hydatidiform mole (D39.2)

Includes

  • choriocarcinoma NOS
  • chorionepithelioma NOS

Clinical Information

  • A malignant metastatic form of trophoblastic tumors. Unlike the hydatidiform mole, choriocarcinoma contains no chorionic villi but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (trophoblasts). It is characterized by the large amounts of chorionic gonadotropin produced. Tissue origins can be determined by dna analyses: placental (fetal) origin or non-placental origin (choriocarcinoma, non-gestational).
  • A malignant neoplasm arising from decidua (placental) cells.
  • A malignant neoplasm arising from placental trophoblast cells. They generally arise in the uterus.
  • A malignant, fast-growing tumor that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta). Almost all choriocarcinomas form in the uterus after fertilization of an egg by a sperm, but a small number form in a testis or an ovary. Choriocarcinomas spread through the blood to other organs, especially the lungs. They are a type of gestational trophoblastic disease.
  • An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hcg) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected.
  • Malignant metastatic form of trophoblastic tumors, contains sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts; characterized by the large amounts of chorionic gonadotropin produced; tissue origins can be placental (fetal) or non-placental.
  • Malignant neoplasm originating in the placenta

Codes

  •  C58 Malignant neoplasm of placenta