2024 ICD-10-CM Diagnosis Code E88.81

by

Metabolic syndrome and other insulin resistance

  • E88.81 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • ICD-10-CM E88.81 is a new 2024 ICD-10-CM code that became effective on October 1, 2023.
  • This is the American ICD-10-CM version of E88.81 – other international versions of ICD-10 E88.81 may differ.

Use Additional

  • codes for associated manifestations, such as:
  • obesity (E66.-)

The following code(s) above E88.81 contain annotation back-references

 that may be applicable to E88.81:

  • E00-E89  Endocrine, nutritional and metabolic diseases
  • E70-E88  Metabolic disorders
  • E88  Other and unspecified metabolic disorders

Approximate Synonyms

  • Drug resistance to insulin
  • Dysmetabolic syndrome x
  • Insulin resistance
  • Metabolic syndrome x

Clinical Information

  • Metabolic syndrome, often referred to as MetS, encompasses a constellation of metabolic risk factors predisposing individuals to cardiovascular diseases and type 2 diabetes mellitus. These risk factors typically include excess abdominal fat, atherogenic dyslipidemia, hypertension, hyperglycemia, insulin resistance, a proinflammatory state, and a prothrombotic state. (from aha/nhlbi/ada conference proceedings, circulation 2004; 109:551-556)
  • It is characterized by a combination of medical conditions such as increased blood pressure, central obesity, abnormal cholesterol levels, and elevated fasting glucose, collectively heightening the risk of heart attack, stroke, and diabetes mellitus.
  • The syndrome is rooted in factors like overweight or obesity, physical inactivity, and genetic predispositions. Its defining features include abdominal obesity, dyslipidemia, raised blood pressure, insulin resistance often accompanied by glucose intolerance, and a propensity towards a prothrombotic and proinflammatory state.
  • Individuals with MetS face an elevated risk of developing diabetes mellitus and various cardiovascular ailments. Although there is ongoing debate among medical professionals regarding its precise definition and causative factors, insulin resistance is commonly implicated. Insulin resistance occurs when the body’s cells become less responsive to insulin, leading to elevated blood sugar levels and laying the groundwork for potential health complications.

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): Deleted code
  • 2024 (effective 10/1/2023): New code

Code annotations containing back-references to E88.81: