2024 ICD-10-CM Diagnosis Code C25.4

Malignant neoplasm of endocrine pancreas

  • C25.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2024 edition of ICD-10-CM C25.4 became effective on October 1, 2023.
  • This is the American ICD-10-CM version of C25.4 – other international versions of ICD-10 C25.4 may differ.

Applicable To

  • Malignant neoplasm of islets of Langerhans

Use Additional

  • code to identify any functional activity.

The following code(s) above C25.4 contain annotation back-references

 that may be applicable to C25.4:

  • C00-D49  Neoplasms
  • C15-C26  Malignant neoplasms of digestive organs
  • C25  Malignant neoplasm of pancreas

Approximate Synonyms

  • Cancer of the islets of langerhans
  • Malignant glucagonoma
  • Primary malignant neoplasm of islets of langerhans

Clinical Information

  • A malignant endocrine neoplasm arising from islets of langerhans of the pancreas.
  • A primary malignant neoplasm of the pancreatic islet cells. Usually it involves the non-insulin-producing cell types, the pancreatic alpha cells and the pancreatic delta cells (somatostatin-secreting cells) in glucagonoma and somatostatinoma, respectively.
  • An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 hpf. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.
  • Cancer arising from cells in the islets of langerhans, which are found in the pancreas.

ICD-10-CM C25.4 is grouped within Diagnostic Related Group(s) (MS-DRG v41.0):

  • 435 Malignancy of hepatobiliary system or pancreas with mcc
  • 436 Malignancy of hepatobiliary system or pancreas with cc
  • 437 Malignancy of hepatobiliary system or pancreas without cc/mcc

Convert C25.4 to ICD-9-CMCode History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change

Code annotations containing back-references to C25.4:

  • Type 1 Excludes: C75C75
  • Type 2 Excludes: C7A

Diagnosis Index entries containing back-references to C25.4: