2024 ICD-10-CM Diagnosis Code A81.2

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Progressive multifocal leukoencephalopathy

  • A81.2 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2024 edition of ICD-10-CM A81.2 became effective on October 1, 2023.
  • This is the American ICD-10-CM version of A81.2 – other international versions of ICD-10 A81.2 may differ.

Applicable To

  • Multifocal leukoencephalopathy NOS

The following code(s) above A81.2 contain annotation back-references

 that may be applicable to A81.2:

  • A00-B99  Certain infectious and parasitic diseases
  • A80-A89  Viral and prion infections of the central nervous system
  • A81  Atypical virus infections of central nervous system

Clinical Information

  • A progressive demyelination within the central nervous system associated with reactivation of a latent jc virus infection.
  • An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., acquired immunodeficiency syndrome and other immunologic deficiency syndromes; hematologic neoplasms; immunosuppression; and collagen diseases). The causative organism is jc polyomavirus (jc virus) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include dementia; ataxia; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (from Joynt, Clinical Neurology, 1996, ch26, pp36-7)
  • Demyelination in various part of the central nervous system, usually secondary to neoplastic disease; jc virus has been recovered from brain tissue.

ICD-10-CM A81.2 is grouped within Diagnostic Related Group(s) (MS-DRG v41.0):

  • 056 Degenerative nervous system disorders with mcc
  • 057 Degenerative nervous system disorders without mcc
  • 974 Hiv with major related condition with mcc
  • 975 Hiv with major related condition with cc
  • 976 Hiv with major related condition without cc/mcc

Convert A81.2 to ICD-9-CMCode History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change

Diagnosis Index entries containing back-references to A81.2: