2024 ICD-10-CM Diagnosis Code A81.1

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Subacute sclerosing panencephalitis

  • A81.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2024 edition of ICD-10-CM A81.1 became effective on October 1, 2023.
  • This is the American ICD-10-CM version of A81.1 – other international versions of ICD-10 A81.1 may differ.

Applicable To

  • Dawson’s inclusion body encephalitis
  • Van Bogaert’s sclerosing leukoencephalopathy

The following code(s) above A81.1 contain annotation back-references

 that may be applicable to A81.1:

  • A00-B99  Certain infectious and parasitic diseases
  • A80-A89  Viral and prion infections of the central nervous system
  • A81  Atypical virus infections of central nervous system

Clinical Information

  • A rare, slowly progressive encephalitis caused by chronic infection with the measles virus. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive myoclonus; muscle spasticity; seizures; dementia; autonomic dysfunction; and ataxia. Death usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the sspe virus, which is a defective variant of measles virus. (from Adams et al., Principles of Neurology, 6th ed, pp767-8)
  • A rare, slowly progressive post-infectious neurological disorder affecting the central nervous system. It is characterized by seizures, ataxia, myoclonus, personality changes, spasticity, and coma. The symptoms appear several years following measles infection at an early age.
  • Rare chronic progressive encephalitis caused by the measles virus and occurring primarily in children and young adults; death usually occurs within three years; characterized by primary measles infection before the age of two years.

ICD-10-CM A81.1 is grouped within Diagnostic Related Group(s) (MS-DRG v41.0):

  • 056 Degenerative nervous system disorders with mcc
  • 057 Degenerative nervous system disorders without mcc
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems

Convert A81.1 to ICD-9-CMCode History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change

Code annotations containing back-references to A81.1:

  • Type 1 Excludes: B05

Diagnosis Index entries containing back-references to A81.1:

  • Bodechtel-Guttman disease A81.1 (subacute sclerosing panencephalitis)
  • Dawson’s A81.1 (inclusion body)
  • Disease, diseased – see also Syndrome
    • Bodechtel-Guttmann A81.1 (subacute sclerosing panencephalitis)
  • Encephalitis (chronic) (hemorrhagic) (idiopathic) (nonepidemic) (spurious) (subacute) G04.90
    • Dawson’s A81.1 (inclusion body)
    • diffuse sclerosing A81.1
    • inclusion body A81.1
    • subacute sclerosing A81.1
    • van Bogaert’s A81.1
  • LeukoencephalitisG04.81
    • subacute sclerosing A81.1
    • van Bogaert’s A81.1 (sclerosing)
  • LeukoencephalopathyG93.49 – see also Encephalopathy
    • van Bogaert’s A81.1 (sclerosing)
  • Panencephalitis, subacute, sclerosing A81.1
  • Van Bogaert’s leukoencephalopathy A81.1 (sclerosing) (subacute)